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Basically, the orchestra of nerves, muscles, neurotransmitters, and interstitial cells of Cajal (ICC) that normally push stool toward the rectum arent working properly, so stool sits and accumulates in the colon for a longer period of time than is normal 3

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Any time youre inhaling something, youre also affecting your mucous membrane, Stevenson said, noting that the drug may have effects on those delicate nasal tissues