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Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions

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75,76 ASOs that employ this mechanism are splicing-switching oligonucleotides, which modulate functional target gene expression by skipping or including exons

Turner RC, Cull CA, Frighi V, Holman RR