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Different sources may reference different titration protocols

J Transl Med (2016) 14:251

Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G, et al

Precautions: Always assess patient for hypersensitivity Administer slowly IV to prevent cardiovascular adverse effects Monitor for signs of allergic or serious systemic reactions Follow up lab monitoring for ongoing deficiency and metabolic status

That is one reason longer phase 3 trials drew so much interest, since the ceiling had not announced itself yet

The treatment also appeared to ameliorate cardiovascular risk, as endothelial function improved by the end of the treatment period