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92 showed that enzymatically increasing the NADH-to-NAD + conversion exclusively in the mitochondria of HeLa cells improves ETC function, highlighting the importance of maintaining high NAD + levels
Additional studies have investigated its influence on vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-?), signaling molecules that play important roles in hair follicle growth, vascularization, and cycling
This observation is consistent with the role of p62 in the degradation of Keap1 in autophagosomal foci
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It also transmits signals for maintaining cellular homeostasis in plants, thereby protecting the plant from stress-induced damage (Noctor 2006)
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