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These proteins are packed into Exos during biogenesis and are situated at the exosomal surface and function as unique markers [47, 63, 74] (Fig

These side effects can be intense enough for an estimated 10% to 20% of patients to stop using GLP-1s, and they tend to be dose dependent meaning that the higher the dose, the more intense or frequent the side effects can be

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CD137 (4-1BB), expressed in CD8 + TILs, acts as a TCR-independent co-stimulatory signal that promotes the exhaustion program as well as the proliferation and terminal differentiation of CD8 + T cells [154]

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