Some people may experience nausea, upset stomach, bloating, or other gastrointestinal issues, particularly after meals
This is revealing, as abnormalities in circadian rhythms are considered to play a potential underlying role in bipolar disorder, as many genes associated with bipolar disorder including CLOCK , PER3 and BMAL1 are regulated in a circadian manner [70,71,72]
(1996) Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function
In a head-to-head trial in adults with obesity or overweight without diabetes, tirzepatide, the active ingredient in Mounjaro and Zepbound led to greater average weight loss than semaglutide over 72 weeks.However, there are various factors to consider when determining which medication is the best fit for an individual's unique needs including cost and insurance coverage, overall health, side effects, and how well the medication aligns with one's lifestyle and goals
Adverse event rates were comparable between groups
Chem Biol Interact 1991