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Evidence of neuroinflammation in the cochlea is also present, including noise-induced activation of NLRP3 inflammasome-mediated inflammatory cascades, but the precise contribution of glial-like cells (e.g., macrophages) in the peripheral auditory system to tinnitus generation remains less well characterized (see Figure 1A) for a schematic of the neuroinflammatory cascade (Mennink et al., 2022)
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