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However, conflicting data exist regarding Treg frequency and function in peripheral blood mononuclear cells (PBMCs) of RA patients (143), with reports of increased (144, 145), normal (136, 137) or reduced (138, 139, 146, 147) numbers, potentially reflecting individual variations and disease activity status

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Both srk kinases syk and lyn and the tyrosine phosphatase PTP1B are redox-sensitive, be it because they possess cysteine residues in the kinase domains or indirectly, because their activity is controlled by the redox- and calcium-sensitive phosphorylation steps mediated in particular by protein kinase C alpha (Bordin et al., 2005