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Pre-Clinical Studies of Synthetic GLP-1/Glucagon Co-Agonists Concurrent to research investigating combination treatments with individual GLP-1 and glucagon infusions, efforts were also focused on optimising the peptide chemistry of native oxyntomodulin, glucagon or GLP-1 in view of designing receptor potent and long-acting synthetic GLP-1/GCG co-agonists

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Intraperitoneal injection of MPTP significantly reduced the levels of dopamine and its metabolites in the striatum