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Participants were randomized 2:1:1:1:1:2:2 to receive placebo or retatrutide at 1 mg, 4 mg (starting at 2 mg), 4 mg (starting at 4 mg), 8 mg (starting at 2 mg), 8 mg (starting at 4 mg), or 12 mg (starting at 2 mg) administered subcutaneously once weekly for 48 weeks

Nasal sprays bypass the GI tract and enter the bloodstream through the olfactory mucosa

It was not a major reason for discontinuation in the trial, but it represents a side effect category that tirzepatide users do not encounter

When these receptors activate, they increase levels of neuropeptide Y and other satiety chemicals while simultaneously reducing hunger-driving hormones like ghrelin

Sofwave may be used alone or as part of a broader physician-directed strategy that includes skincare or other aesthetic treatments