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Antioxidant Defense Mechanism It is important to note that while free radicals and ROS are normal byproducts of cellular metabolism, their excessive and uncontrolled production can lead to oxidative stress, which can damage cellular components by oxidizing lipids, disrupting protein structure, and causing DNA strand breaks [39], thereby contributing to impaired cellular function, tissue inflammation, and the development or progression of CLD [40]

The significant increase in taurine, xanthine, and glutathione in tamoxifen-resistant cells indicates an increase in antioxidative activity in the cells, especially in the cell line under continuous tamoxifen treatment

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6 days after injection, 25 mice were randomly divided into five groups ( n = 5)