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It is plausible that the two siblings may carry different GLP1R genotypes: the sister might harbor the rs6923761 AA variant, which is associated with a higher weight loss rate, while the brother may carry the GG or GA variant that weakens semaglutide efficacy

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Tests in obese mice indicated the triple agonist was more powerful than dual agonists in correcting obesity and diabetes (Finan, Yang, Ottaway)

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