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Diagnostic tests

Because metformin hydrochloride is dialyzable (with a clearance of up to 170 mL/min under good hemodynamic conditions), prompt hemodialysis is recommended to correct the acidosis and remove the accumulated metformin

Consequently, the commercial and regulatory strategy for MC4R-targeted therapies has logically shifted toward indications with more predictable and homogeneous patient populations

Common side effects In the SUSTAIN trials, the most frequently reported side effects with semaglutide were: 5 Nausea: 11-20% of participants (compared to 3-8% with placebo) Diarrhoea: 4.5-11% of participants Vomiting: 4-11.5% of participants Constipation: Common, particularly in early weeks These side effects are typically mild to moderate and tend to improve as your body adjusts to the medication

But I'd say that for most patients, at least in my experience, in my practice, they can handle the sugar-apples pretty well

Stat Med (2011) 30(4):37799