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"The key question will be whether future research demonstrates a meaningful performance-enhancing effect independent of their therapeutic role in treating obesity and metabolic disease."

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The American Society of Anesthesiologists (ASA) has provided guidance on GLP-1-RA use prior to surgery based on the pharmacological half-life, advising that daily medications should be held a day before surgery, and weekly GLP-1-RA should be held a week before surgery

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Estradiol also interacts with peripherally synthetized peptides, such as CCK, leptin and insulin