In this study we investigate the safety of copper complex of glycyl-L-histidyl-L-lysine (GHK-Cu), copper chloride (CuCl 2 ) and copper acetate (Cu(OAc) 2 ) by using in vitro skin irritation tests
Additionally, the possibility of interactions with other peptides or compounds highlights the necessity for careful consideration of patient safety and specific needs
Note: The inhibitors of glutathione S-transferase (GST) isoforms are listed in the DrugBank
GHK-Cu Side Effects Topical GHK-Cu is generally well-tolerated by most skin types, but some individuals may experience mild irritation
Mechanism 2: Increased Follicle Enlargement Research published in the Journal of Investigative Dermatology found that GHK-Cu increased follicle size by approximately 46% in study models consistent with the known effect of vascular growth factors that GHK-Cu upregulates (VEGF in particular drives nutrient delivery to follicles)
For researchers studying skin biology, collagen networks, wound repair, or photoaging pathways, this topical GHK-Cu serum provides a research-ready delivery format with verified purity and batch documentation
