Medical and nutritional science continually evolves, and what is considered best practice today might change as new evidence comes to light
As reviewed in our previous newsletters and blog, semaglutide is part of a new class of medications that have revolutionized obesity medicine
Other popular options that people usually think of are: weight loss pills, behavioural programs food plans, and even surgical procedures
While conceptually this is a discrete step, it is often overlooked or lumped in with other parts of the process
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Disrupting this pathwayeither by severing kidney sensory nerves, selectively deleting the angiotensin II type 1a receptor (AT1a) in the subfornical organ (SFO), or using optogenetics to silence the kidney-SFO or SFO-paraventricular nucleus (PVN) connectionsreduces sympathetic output, which in turn diminishes structural damage and functional impairment in the kidneys and heart in these models of CKD and heart failure (Cao et al., 2023)
