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Melanocortin receptors, a family of G-protein-coupled receptors, appear to mediate the actions of -MSH and the synthetic MT-1 and related peptides, impacting biological processes such as pigmentation, hunger hormone regulation, energy balance, copulatory function, and certain neural activities

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The study also compared GLP-1 receptor agonists with other second-line diabetes medications like empagliflozin (Jardiance), dapagliflozin (Farxiga), and sitagliptin (Januvia) to see how these medications stacked up against each other in terms of mental health effects

doi: 10.1038/s41591-019-0396-4 100 Valles-ColomerMFalonyGDarziYTigchelaarEFWangJTitoRYet al