GLP-1 is a pleiotropic hormone with numerous functions besides glucose control
For diabetes patients, A1c reductions of approximately 1.0-1.5 percentage points are common with GLP-1 receptor agonists, while tirzepatide has shown reductions of up to 2.0-2.3 percentage points in clinical trials
Tinsley, Steven B
Furthermore, these increased levels of pro-inflammatory cytokines resulted in an increase of corticotropin-releasing hormone activity and hyperactivity of the HPA axis in most patients with depression (Kopschina Feltes et al., 2017)
Back Zander, M, Madsbad, S, Madsen, JL, Holst, JJ (9 March 2002) 'Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study', The Lancet , 359/9309, 824-30
A heavy dinner 90 minutes prior is not