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(2021) trial tested cagrilintide at 0.3-4.5 mg weekly for 26 weeks in 706 adults: (Lau et al., 2021) Semaglutide Monotherapy (Phase 3) The STEP 1 trial tested semaglutide 2.4 mg weekly for 68 weeks in 1,961 adults: Mean weight loss: -14.9% =10% threshold: ~70% =15% threshold: ~54% =20% threshold: ~32% Important caveat: The semaglutide trial was 68 weeks versus only 26 weeks for cagrilintide