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Am J Physiol Renal Physiol 301(2):F355F363 Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J et al (2009) A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

The latter differentiation depends on the sustained ability of short-acting GLP-1 receptor agonists to delay gastric emptying by inhibiting gastric motility, as tachyphylaxia of this effect appears after long-term GLP-1 receptor agonism [3]

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