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Most protocols run 4 to 12 weeks followed by a 2 to 4 week rest period

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There is a lot of information there and understanding the results can be difficult

139 Initially, it was hypothesized that the loss or reduction of ABCG2-mediated renal urate secretion would result in increased renal urate reabsorption, as diminished renal excretion is typically considered the primary mechanism of hyperuricemia in most gout patients

Conservative dosing, interval monitoring, clear stopping criteria, and documentation rigorous enough that the data contributes to the evidence base rather than just adding another anecdote