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BBD is a valuable method that measures glutathione concentration, peroxide concentration, and incubation time to attain optimum GPx activity (see Table 3)

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The importance of these cerebrovascular functional measures are supported by the graded relationship between impairment in cerebrovascular reactivity to CO 2 (Kim et al., 2021

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Consequently, the decreased PHD activity leads to HIF-1 stabilization (39)

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