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These tetrapeptides exhibit antifungal activity akin to alpha-melanocyte-stimulating hormone (-MSH), and theoretical calculations have elucidated their biologically relevant conformation and minimal structural requirements for antifungal response, guiding future compound design

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FIGURE 33 The time course of drug accumulation and elimination

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Easier patient recruitment will allow analysis of larger and more representative populations, while subgroup analysis may help elucidate efficacy in a more selective green knee population