They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer
EVOKE/EVOKE+ design (Phase 3 semaglutide in early AD)
Another study reported a 25% reduction in melanin production with continued use (NIH)
Barnett C, Costill DL, Vukovich MD, Cole KJ, Goodpaster BH, Trappe SW, Fink WJ (1994) Effect of l-carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sprint cycling
We often find that treatment is contraindicated if theres a history of rapid GFR decline
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