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For researchers with pre-existing cardiovascular conditions or those taking medications that affect heart rate, this difference is particularly relevant

They can adjust your medication or dosage based on your progress to ensure it continues to support your overall health

One exception to the injectable formulations is semaglutide (Rybelsus), which is available as an oral tablet

Accessed May 20, 2026

A prospective cohort study compared the effect of metformin as monotherapy versus metformin with additional therapy of either insulin or GLP-1 RA on lung function in 32 non-asthmatic patients with T2D over 2 years [99]

That shift in understanding is important regardless of how any individual chooses to address it