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According to the FDA, consumers should be cautious of claims that suggest a compounded medication: Is a "generic" version of an FDA-approved drug Has been FDA-approved or evaluated by the FDA for safety and effectiveness Is clinically proven to provide the same results as an FDA-approved medication Is sourced from an "FDA-approved" or "FDA-licensed" pharmacy or outsourcing facility Is being marketed in a way that implies the telehealth company is the actual compounder It's important to understand that compounded medications are not reviewed by the FDA for safety, effectiveness, or quality before they are marketed
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From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies
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