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CD36 activation by lipid peroxidation products, like 4-hydroxy-trans-2-nonenal (4HNE), leads to the induction of ER stress markers such as phospho-ATF4 and CHOP in endothelial cells

Ozempic is FDA approved for use in adults with type 2 diabetes to help: manage blood sugar levels, along with a healthy diet and exercise reduce the risk of major cardiovascular (heart or blood vessel) problems in people who also have cardiovascular disease reduce the risk of worsening kidney disease and death from cardiovascular disease in people who also have chronic kidney disease There has been increasing interest in using Ozempic for weight loss, but there is currently not enough evidence to support the safe and effective use of Ozempic for weight loss

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Wang Y, Tao X, Tang X-M, Xiao L, J-l S, Yan X-F, Li D, Deng H-Y, Ma X-R

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