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A Mendelian randomization study in Frontiers in Endocrinology found that genetically predicted higher insulin resistance was associated with worse cognitive performance, with changes in brain cortical structure mediating part of the effect

System X c is driven by concentrations gradient from extracellular Cys and intracellular Glu, transporting Cys and Glu in a 1:1 ratio (Figure 1)

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This effect is dose-dependent and typically transient, resolving as patients acclimate to therapy

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& Kochevar, I