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NICE guidance (NG207) acknowledges that weight maintenance after initial loss represents a clinically meaningful outcome, as preventing weight regain offers substantial health benefits including improved cardiovascular risk profile and glycaemic control

These are some of the most serious issues tied to the drugs: Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) A rare condition where reduced blood flow to the optic nerve causes sudden, painless vision loss that can be permanent

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Activation and modulation of the AGEs-RAGE axis: implications for inflammatory pathologies and therapeutic interventions a review

Findings from the ResearchGate [4] preclinical study also demonstrate similar gene-level modulation

So its important to introduce them carefully to avoid potential side effects like irritation