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To reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes with known heart disease

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Mechanisms: MT-I primarily activates the MC1R, while MT-II has increased affinity towards the MC3R and MC4R [6, 9]

Brain short-chain fatty acids induce ACSS2 to ameliorate depressive-like behavior via PPARgamma-TPH2 Axis

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