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Both approaches share the same principle of gradual escalation

Moreover, biodegradable MPs increased potentially harmful Megamonas and Prevotella with SCFA production impairment, authors hypothesizing that biodegradable plastics may cause greater harm than conventional plastics because their degradation creates oligomerssmaller breakdown products that can more easily penetrate biological barriers and further exhibit detrimental effects on gut microbiota (Peng et al., 2024)

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3.1 Dopaminergic Drugs Pharmacological dopamine substitution is the mainstay of medical management of PD motor symptoms and levodopa combined with a dopa decarboxylase inhibitor (DDCI) still remains the gold-standard of symptomatic efficacy [3, 6,7,8,9, 14]

Edney LC, Haji Ali Afzali H, Cheng TC, Karnon J (2018) Estimating the reference incremental cost-effectiveness ratio for the Australian health system

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