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Plainsboro, NJ: Novo Nordisk, Inc

Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment

They are indicated for type 2 diabetes management and chronic weight management, though patients may experience joint symptom improvements as a secondary benefit of weight loss

Risks and Considerations GLP-1 microdosing is an off-label practice

While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation

ET on Nov 22, 2025 Medication Safety 2 3 What important safety information should I know