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During the off-cycle, IGF-1R gene expression rebounds, cell surface receptor density normalizes, and IRS-1 sensitivity to phosphorylation returns to baseline

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This has led researchers to investigate a possible association with premature graying

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Here is an example of one study done in adolescents

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We do this to reduce the possibility of peptide tolerance while providing a buffer against potential risks from chronic exposure

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Working with a registered dietitian to ensure nutrient-dense food choices within reduced caloric intake can help prevent deficiency-related brain fog

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