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This process establishes a positive feedback loop in which ANGPTL4 sustains profibrotic signaling through TGF-, while TGF- signaling further upregulates ANGPTL4 gene expression (Srivastava et al., 2024

(PubMed) Lowik MR, van den Berg H, Kistemaker C, Brants HA, Brussaard JH

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Given the myriad of challenges in managing irAEs, the focus has shifted towards tools that prevent irAEs

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