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[DOI] [PubMed] [Google Scholar] 129.Hager K., Kenklies M., McAfoose J., Engel J., Mnch G

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There are three main biotransformation pathways (see Figure 2) involved in methamphetamine metabolic clearance: (1) N-demethylation to produce amphetamine, (2) aromatic hydroxylation producing 4-hydroxymethamphetamine (pholedrine) with both reactions partially regulated by CYP2D6 (Lin et al., 1997), and (3) beta-hydroxylation to produce norephedrine

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