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Some patients might find a once-daily pill less daunting and more discreet

If you experience any discomfort during use

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Now anyone who is obese as defined by body mass index (BMI) or who is overweight per BMI and has at least one weight-related health condition is eligible for a GLP-1 prescription

Mechanisms of Action and Therapeutic Rationale Physiological Basis of GLP-1 Action GLP-1, an incretin hormone, plays a crucial role in glucose metabolism and appetite regulation, influencing insulin secretion, insulin-sensitivity, and gastric emptying [15] [16]

Patients who switched from tirzepatide to orforglipron maintained a mean 74.7% of their body weight reduction from the SURMOUNT-5 trial compared with those in the placebo group, which maintained a mean 49.2% of their weight loss