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10.1146/annurev-physiol-042222-030731 25 SaadatiS.KabthymerR

The capillaries of the glomerulus are relatively impermeable to proteins and constituents of cells such that the composition of the glomerular filtrate is similar to that of the plasma

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IV administration produces direct systemic exposure, but evidence for elective wellness benefits remains limited

Immortalized cell lines, while convenient and reproducible, often lack the functional complexity, genetic diversity, and physiological responses of primary kidney cells, limiting their ability to model individual variations in renal function and pathology