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On average the center of mass distance between two GalCer sugars is around 0.6 nm allowing sugar ring hydrophobic packing

Contribution statement RM conducted the analyses, prepared tables and figures, interpreted the data and co-wrote the manuscript

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These findings strongly support the hypothesis that by reducing systemic oxidative stress and improving cerebral microcirculation, Pycnogenol can effectively protect the brain from premature cognitive decline and functional impairment

This is why athletes, active individuals, and people exposed to heat often focus on both water and electrolyte intake rather than relying exclusively on plain water