Insulin release is mediated by enzymatic cleavage of CS/GS To examine the release of the insulin payload, we measured carbon-14 ( 14 C) insulin ( 14 C-INS) release from QD-INSCS/GS using co-incubation with various hydrolysis enzymes, low pH values and temperatures in hepatocyte cultures

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10.1172/JCI22422 23
[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Yang X., Deignan J.L., Qi H., Zhu J., Qian S., Zhong J., Torosyan G., Majid S., Falkard B., Kleinhanz R.R., et al
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