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BH4 is an essential cofactor and plays multiple roles in the regulation of oxidative stress and inflammation ( DHODH, within the mitochondria, is an enzyme that generates ubiquinol by catalyzing the conversion of the molecule dihydroorotate (DHO) to orotate (OA)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Kern JK, Geier DA, Adams JB, Garver CR, Audhya T, Geier MR

Bogaert and Damme 2006)

Research has shown, for example, that raising glutathione may even aid conditions like fatty liver disease by reducing oxidative damage in liver cells