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The potential of GLP-1RAs to induce psychiatric adverse events is biologically plausible given the widespread expression of GLP-1 receptors in the central nervous system, 167 their influence on neurocognitive function, 168 and their effects on inflammation, stress response, and energy metabolism, which theoretically could improve mood

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Was the response allele also associated with higher initial body mass/BMI

From 7.5 to 10 mg, GLP-1 engagement roughly doubles from the 5 mg level