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History of Gastroparesis or Pancreatitis Both medications may worsen these gastrointestinal conditions and should not be used by individuals with a history of severe gastroparesis or pancreatitis

Coverage rules still vary by province or territory

Digestive Changes Diarrhea or constipation may occur as the drug slows gastric emptying

Results announced in September 2025 and published in The Lancet in February 2026 demonstrated orforglipron's superiority over oral semaglutide on both HbA1c reduction (approximately 2.2 vs 1.4 percentage points) and weight loss (approximately 9.2% vs 5.3%)

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Schedule 9 Prohibited Substance Substances prohibited for manufacture, supply, or use except under exceptional circumstances, often for research purposes