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Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration

However, vitamin injections require administration by a healthcare professional, which can minimize the risk of incorrect dosing and potential side effects

Notwithstanding several setbacks, such as the cessation of Alnylams siRNAGalNAc conjugate and CureVacs mRNA vaccination studies, the field persists in its advancement, evidenced by FDA approval of many ASOs and a plethora of RNA-based therapeutics with improved modifications advancing through late-stage trials

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Kass D, Bridges RS, Borczuk A, Greenberg S

But the biggest challenge for the acetate form is pH sensitivity