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In the past 8 years, four meta-analyses, including 1626 RCTs each, have pooled the data from studies comparing prostaglandin E1 (PE1) with and without B12 and with or without additional alpha-lipoic acid

Microbiome-targeted therapeutic interventions such as prebiotics, probiotics, and fecal microbiota can be promising as an adjunctive treatment for depression disorder

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