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One such adaptation she and her colleagues have been studying is an increase in the amount of the enzyme glutamine synthetase, which makes glutamine from other starting materials, namely glucose

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Renal protection by sodium-glucose cotransporter 2 inhibitors and its underlying mechanisms in diabetic kidney disease

320 Although all cystines located on the surface of p53 can be modified by the Michael addition reaction, cystine 124 is considered the most important site

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So, I think the real hit here is going to be from the higher costs acting like a drag on consumer spending