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Treatment recommendations are made following professional clinical judgement, with patient safety and best practice at the core

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Best for: People sensitive to methyl-B12 Those with histamine intolerance or mast cell issues Overmethylators or those with anxiety from methylated vitamins Detoxification support (binds to toxins like cyanide and nitric oxide) Balanced, gentle B12 support Advantages: Body controls conversion rate (less likely to cause overmethylation) Supports detoxification pathways Well-tolerated by most people Longer-lasting in the body than methyl-B12 Potential downsides: Requires conversion (may be less efficient with severe MTHFR mutations) Slightly less direct methylation support than methyl-B12 Can be harder to find in supplements Typical dosage: 1000-5000mcg daily 3

10.1186/s13024-021-00463-2 58 OttoL

This includes those with conditions like pernicious anemia, certain gastrointestinal disorders, or age-related absorption issues

In summary, our newly introduced method offers an innovative approach for uncovering the substrate landscape of the 20S proteasome