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We performed ancestry-specific GWAS analyses for each group of European, African, and Admixed American/Latino ancestries to explore genetic associations unique to each ancestry

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*Patients on iron tablets will have black stool, so ensure to clarify the temporal sequence for any symptoms with the starting of iron tablets Investigations Initial Investigations All patients with suspected melena should undergo routine blood tests , including FBC, U&Es, LFTs, and clotting, to help investigate for underlying causes and to stratify overall risk

Specifically, patients should seek medical attention if they experience severe abdominal pain, particularly if localized to the upper abdomen or radiating to the back, as this may indicate pancreatitis a rare but serious adverse effect associated with GLP-1 receptor agonists

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Check Your Minerals: Minerals like selenium and zinc are cofactors for glutathione enzymes