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doi:10.1186/s12894-019-0492-2
Many of us dont receive all the vitamins and minerals our body needs through diet, but supplements can provide the additional support we need in order to maintain balance
Together, they may work synergistically to accelerate tissue regeneration and suppress inflammatory responses by targeting overlapping and complementary pathways 1-4
Hepatic cytochrome P450 isoenzymes CYP1A2 and CYP3A4 mediate N-de-ethylation, so polymorphisms or competitive inhibition at these pathways (e.g., by certain antidepressants or azole antifungals) may increase systemic exposure, underscoring the importance of individualizing dosage and monitoring serum concentrations in prolonged infusions
These findings are specific to controlled animal models and are used to better understand how NNMT and related pathways influence energy storage and utilization, not to support clinical or therapeutic conclusions
