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IGF-1 receptors undergo ligand-induced internalization and degradation when chronically stimulated, reducing cell surface receptor density by 3050% within 34 weeks in myocyte culture models

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Maintaining a healthy diet and exercise routine can help manage this effect

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A 72-week trial carried out on Wegovy found that patients using the 7.2 mg maintenance dose achieved, on average, a change in body weight of 21% compared to 2.4% in the placebo group