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[24,59,60] hCDR1 also downregulated IL-1, IFN-, and TNF- in addition to IFN-, and upregulated the immunosuppressive cytokine transforming growth factor- (TGF-)

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Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials